5JYC
 
 | | Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate | | Descriptor: | (5~{Z},11~{Z},14~{R},15~{R})-14,15-bis(oxidanyl)icosa-5,8,11-trienoic acid, CFTR inhibitory factor | | Authors: | Hvorecny, K.L, Madden, D.R. | | Deposit date: | 2016-05-13 | | Release date: | 2017-01-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8TRN
 | | Actin 1 from T. gondii in filaments bound to MgADP and jasplakinolide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, Jasplakinolide, ... | | Authors: | Hvorecny, K.L, Sladewski, T.E, Heaslip, A.T, Kollman, J.M. | | Deposit date: | 2023-08-09 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover.
Nat Commun, 15, 2024
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8TRM
 | | Actin 1 from T. gondii in filaments bound to MgADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION | | Authors: | Hvorecny, K.L, Sladewski, T.E, Heaslip, A.T, Kollman, J.M. | | Deposit date: | 2023-08-09 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover.
Nat Commun, 15, 2024
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5HK9
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5HKB
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5HKA
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8DBE
 | | Human PRPS1 with ADP; Hexamer | | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBO
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8DBF
 | | Human PRPS1 with ADP; Filament Interface | | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBG
 | | Human PRPS1 with Phosphate and ATP; Hexamer | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBL
 | | Human PRPS1 with Phosphate and PRPP; Hexamer | | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBN
 | | Human PRPS1-E307A engineered mutation with Phosphate, ATP, and R5P; Hexamer | | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBJ
 | | Human PRPS1 with Phosphate, ATP, and R5P; Filament Interface | | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBK
 | | Human PRPS1 with Phosphate, ATP, and R5P; Hexamer with resolved catalytic loops | | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBC
 | | Human PRPS1 with Phosphate; Hexamer | | Descriptor: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase 1 | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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8DBM
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8DBH
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8DBD
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8DBI
 | | Human PRPS1 with Phosphate, ATP, and R5P; Hexamer | | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hvorecny, K.L, Kollman, J.M. | | Deposit date: | 2022-06-14 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2 Å) | | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity.
Nat.Struct.Mol.Biol., 30, 2023
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5TNH
 | | Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 17,18-EpETE hydrolysis intermediate | | Descriptor: | (5Z,8Z,11Z,14Z,17R,18R)-17,18-dihydroxyicosa-5,8,11,14-tetraenoic acid, CFTR inhibitory factor | | Authors: | Hvorecny, K.L, Madden, D.R. | | Deposit date: | 2016-10-14 | | Release date: | 2017-10-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
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5TNS
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5TNF
 | | Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 19,20-EpDPE hydrolysis intermediate | | Descriptor: | (4Z,7Z,10Z,13Z,16Z,19R,20R)-19,20-dihydroxydocosa-4,7,10,13,16-pentaenoic acid, CFTR inhibitory factor | | Authors: | Hvorecny, K.L, Madden, D.R. | | Deposit date: | 2016-10-14 | | Release date: | 2017-10-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
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5TNQ
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5TNJ
 | | Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 4-Vinyl-1-cyclohexene 1,2-epoxide hydrolysis intermediate | | Descriptor: | (1R,2R,4R)-4-ethenylcyclohexane-1,2-diol, (1R,2R,4S)-4-ethenylcyclohexane-1,2-diol, (1S,2S,4R)-4-ethenylcyclohexane-1,2-diol, ... | | Authors: | Hvorecny, K.L, Madden, D.R. | | Deposit date: | 2016-10-14 | | Release date: | 2017-10-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
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5TNN
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