8DBN

Human PRPS1-E307A engineered mutation with Phosphate, ATP, and R5P; Hexamer

Summary for 8DBN

Entry DOI	10.2210/pdb8dbn/pdb
EMDB information	27291
Descriptor	Ribose-phosphate pyrophosphokinase 1, ADENOSINE-5'-TRIPHOSPHATE, 5-O-phosphono-alpha-D-ribofuranose, ... (4 entities in total)
Functional Keywords	phosphoribosyl pyrophosphate synthetase, atp/r5p substrate, filament-breaking mutation, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	213377.92
Authors	Hvorecny, K.L.,Kollman, J.M. (deposition date: 2022-06-14, release date: 2023-02-15, Last modification date: 2023-03-29)
Primary citation	Hvorecny, K.L.,Hargett, K.,Quispe, J.D.,Kollman, J.M. Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30:391-402, 2023 Cited by PubMed: 36747094 DOI: 10.1038/s41594-023-00921-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.4 Å)

Structure validation