5JYC

Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate

Summary for 5JYC

Entry DOI	10.2210/pdb5jyc/pdb
Descriptor	CFTR inhibitory factor, (5~{Z},11~{Z},14~{R},15~{R})-14,15-bis(oxidanyl)icosa-5,8,11-trienoic acid (3 entities in total)
Functional Keywords	epoxide hydrolase, hydroxyalkyl-enzyme intermediate, hydrolase
Biological source	Pseudomonas aeruginosa (strain UCBPP-PA14)
Total number of polymer chains	4
Total formula weight	138008.79
Authors	Hvorecny, K.L.,Madden, D.R. (deposition date: 2016-05-13, release date: 2017-01-11, Last modification date: 2023-09-27)
Primary citation	Flitter, B.A.,Hvorecny, K.L.,Ono, E.,Eddens, T.,Yang, J.,Kwak, D.H.,Bahl, C.D.,Hampton, T.H.,Morisseau, C.,Hammock, B.D.,Liu, X.,Lee, J.S.,Kolls, J.K.,Levy, B.D.,Madden, D.R.,Bomberger, J.M. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc. Natl. Acad. Sci. U.S.A., 114:136-141, 2017 Cited by PubMed: 27980032 DOI: 10.1073/pnas.1610242114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation