8DBM

Human PRPS1 with Phosphate and PRPP; Filament Interface

Summary for 8DBM

Entry DOI	10.2210/pdb8dbm/pdb
EMDB information	27290
Descriptor	Ribose-phosphate pyrophosphokinase 1, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	phosphoribosyl pyrophosphate synthetase, prpp product, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	12
Total formula weight	424425.26
Authors	Hvorecny, K.L.,Kollman, J.M. (deposition date: 2022-06-14, release date: 2023-02-15, Last modification date: 2023-03-29)
Primary citation	Hvorecny, K.L.,Hargett, K.,Quispe, J.D.,Kollman, J.M. Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30:391-402, 2023 Cited by PubMed: 36747094 DOI: 10.1038/s41594-023-00921-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.4 Å)

Structure validation