Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 24 results
2RCR
DownloadVisualize
BU of 2rcr by Molmil
STRUCTURE OF THE MEMBRANE-BOUND PROTEIN PHOTOSYNTHETIC REACTION CENTER FROM RHODOBACTER SPHAEROIDES
Descriptor: BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, Coenzyme Q10, ...
Authors:Chang, C.-H, Norris, J, Schiffer, M.
Deposit date:1991-02-04
Release date:1993-07-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the membrane-bound protein photosynthetic reaction center from Rhodobacter sphaeroides.
Biochemistry, 30, 1991
1HVR
DownloadVisualize
BU of 1hvr by Molmil
RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
Descriptor: HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-HEXAHYDRO-5,6-DIHYDROXY-1,3-BIS[2-NAPHTHYL-METHYL]-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPIN-2-ONE
Authors:Chang, C.-H.
Deposit date:1994-02-14
Release date:1995-01-26
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
Science, 263, 1994
3CEN
DownloadVisualize
BU of 3cen by Molmil
Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide
Descriptor: COAGULATION FACTOR X, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Chang, C.-H.
Deposit date:2008-02-29
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties
Bioorg.Med.Chem.Lett., 18, 2008
2P93
DownloadVisualize
BU of 2p93 by Molmil
Factor xa in complex with the inhibitor 5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide
Descriptor: 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE, Factor Xa
Authors:Chang, C.-H.
Deposit date:2007-03-23
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17, 2007
2P94
DownloadVisualize
BU of 2p94 by Molmil
Factor xa in complex with the inhibitor 3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclohexyl)-1H-indole-6-carboxamide
Descriptor: 3-CHLORO-N-((1R,2S) -2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)CYCLOHEXYL)-1H-INDOLE-6-CARBOXAMIDE, Factor Xa
Authors:Chang, C.-H.
Deposit date:2007-03-23
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17, 2007
2P95
DownloadVisualize
BU of 2p95 by Molmil
Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide
Descriptor: 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE, Factor Xa
Authors:Chang, C.-H.
Deposit date:2007-03-23
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17, 2007
1DMP
DownloadVisualize
BU of 1dmp by Molmil
STRUCTURE OF HIV-1 PROTEASE COMPLEX
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE
Authors:Chang, C.-H.
Deposit date:1996-11-01
Release date:1997-11-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.
Chem.Biol., 3, 1996
1HWR
DownloadVisualize
BU of 1hwr by Molmil
MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS
Descriptor: HIV-1 PROTEASE, [4-R-(4-ALPHA,6-BETA,7-BETA]-HEXAHYDRO-5,6-DI(HYDROXY)-1,3-DI(ALLYL)-4,7-BISPHENYLMETHYL)-2H-1,3-DIAZEPINONE
Authors:Chang, C.-H.
Deposit date:1998-03-20
Release date:1999-03-23
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular recognition of cyclic urea HIV-1 protease inhibitors.
J.Biol.Chem., 273, 1998
1HVH
DownloadVisualize
BU of 1hvh by Molmil
NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS
Descriptor: HIV-1 PROTEASE, {[4-R(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS(4-HYDROXYMETHYL)METHYL]-4,7-BIS(PHENYLMETHYL) -2H-1,3-DIAZEPIN-2-YLIDENE]CYANAMIDE}
Authors:Chang, C.-H.
Deposit date:1997-12-13
Release date:1998-12-30
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.
J.Med.Chem., 41, 1998
1MET
DownloadVisualize
BU of 1met by Molmil
HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
5LVE
DownloadVisualize
BU of 5lve by Molmil
STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
Descriptor: BENCE-JONES PROTEIN LEN, ZINC ION
Authors:Schiffer, M, Huang, D.-B, Chang, C.-H.
Deposit date:1999-02-24
Release date:2000-02-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Change in dimerization mode by removal of a single unsatisfied polar residue located at the interface.
Protein Sci., 9, 2000
1LVE
DownloadVisualize
BU of 1lve by Molmil
STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
Descriptor: LEN, A VARIABLE DOMAIN FROM KAPPA-4 TYPE
Authors:Schiffer, M, Huang, D.-B, Chang, C.-H.
Deposit date:1996-07-17
Release date:1998-01-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Variable domain structure of kappaIV human light chain Len: high homology to the murine light chain McPC603.
Mol.Immunol., 34, 1997
2C6Y
DownloadVisualize
BU of 2c6y by Molmil
Crystal structure of interleukin enhancer-binding factor 1 bound to DNA
Descriptor: FORKHEAD BOX PROTEIN K2, INTERLEUKIN 2 PROMOTOR, MAGNESIUM ION
Authors:Tsai, K.-L, Huang, C.-Y, Chang, C.-H, Sun, Y.-J, Chuang, W.-J, Hsiao, C.-D.
Deposit date:2005-11-15
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Human Foxk1A-DNA Complex and its Implications on the Diverse Binding Specificity of Winged Helix/Forkhead Proteins.
J.Biol.Chem., 281, 2006
2A3S
DownloadVisualize
BU of 2a3s by Molmil
Solution structure and Dynamics of DNA-Binding Domain of Myocyte Nuclear Factor
Descriptor: Myocyte Nuclear Factor
Authors:Chuang, W.-J, Chang, C.-H, Jeng, W.-Y, Chu, Y.-P.
Deposit date:2005-06-27
Release date:2006-06-13
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure and Dynamics of DNA-Binding Domain of Myocyte Nuclear Factor
to be published
2D2W
DownloadVisualize
BU of 2d2w by Molmil
Solution structure and Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor
Descriptor: Forkhead box protein K1
Authors:Chuang, W.-J, Chang, C.-H, Jeng, W.-Y, Chu, Y.-P.
Deposit date:2005-09-19
Release date:2006-09-05
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution Structure and Backbone Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor (Foxk1)
TO BE PUBLISHED
1MEU
DownloadVisualize
BU of 1meu by Molmil
HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
1MER
DownloadVisualize
BU of 1mer by Molmil
HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
1MES
DownloadVisualize
BU of 1mes by Molmil
HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
1QBT
DownloadVisualize
BU of 1qbt by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Descriptor: HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE]
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-25
Release date:1997-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40, 1997
1QBR
DownloadVisualize
BU of 1qbr by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Descriptor: HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-3,3'-[[TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-D IYL] BIS(METHYLENE)]BIS[N-2-THIAZOLYLBENZAMIDE]
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-25
Release date:1997-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40, 1997
1QBU
DownloadVisualize
BU of 1qbu by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Descriptor: HIV-1 PROTEASE, [4R--(1ALPHA,5ALPHA,7BETA)]-3-[(CYCLOPROPHYLMETHYL)HEXAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPIN] METHYL-2-THIAZOLYLBENZAMIDE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-25
Release date:1997-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40, 1997
1QBS
DownloadVisualize
BU of 1qbs by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-25
Release date:1997-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
J.Med.Chem., 39, 1996
1KIG
DownloadVisualize
BU of 1kig by Molmil
BOVINE FACTOR XA
Descriptor: ANTICOAGULANT PEPTIDE, FACTOR XA
Authors:Wei, A, Alexander, R, Chang, C.-H.
Deposit date:1997-04-24
Release date:1998-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Unexpected binding mode of tick anticoagulant peptide complexed to bovine factor Xa.
J.Mol.Biol., 283, 1998
1FT4
DownloadVisualize
BU of 1ft4 by Molmil
PHOTOCHEMICALLY-ENHANCED BINDING OF SMALL MOLECULES TO THE TUMOR NECROSIS FACTOR RECEPTOR-1
Descriptor: 5-(3-MORPHOLIN-4-YL-PROPYL)-2-(3-NITRO-PHENYL)-4-THIOXO-4,5-DIHYDRO-1-THIA-3B,5-DIAZA-CYCLOPENTA[A]PENTALEN-6-ONE, SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1
Authors:Muckelbauer, J.K, Chang, C.-H.
Deposit date:2000-09-11
Release date:2001-10-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
Proc.Natl.Acad.Sci.USA, 98, 2001

219140

PDB entries from 2024-05-01

PDB statisticsPDBj update infoContact PDBjnumon