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1HVR

RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS

Summary for 1HVR
Entry DOI10.2210/pdb1hvr/pdb
DescriptorHIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-HEXAHYDRO-5,6-DIHYDROXY-1,3-BIS[2-NAPHTHYL-METHYL]-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPIN-2-ONE (2 entities in total)
Functional Keywordshydrolase, acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains2
Total formula weight22154.08
Authors
Chang, C.-H. (deposition date: 1994-02-14, release date: 1995-01-26, Last modification date: 2017-11-29)
Primary citationLam, P.Y.,Jadhav, P.K.,Eyermann, C.J.,Hodge, C.N.,Ru, Y.,Bacheler, L.T.,Meek, J.L.,Otto, M.J.,Rayner, M.M.,Wong, Y.N.,Chang, C.-H.,Weber, P.,Jackson, D.A.,Sharpe, T.R.,Erickson-Viitanen, S.
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
Science, 263:380-384, 1994
Cited by
PubMed: 8278812
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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