1HVH

NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS

Summary for 1HVH

• Entry DOI: 10.2210/pdb1hvh/pdb
• Descriptor: HIV-1 PROTEASE, {[4-R(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS(4-HYDROXYMETHYL)METHYL]-4,7-BIS(PHENYLMETHYL) -2H-1,3-DIAZEPIN-2-YLIDENE]CYANAMIDE} (3 entities in total)
• Functional Keywords: hydrolase, acid protease
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• Total number of polymer chains: 2
• Total formula weight: 22106.04

Authors

Chang, C.-H. (deposition date: 1997-12-13, release date: 1998-12-30, Last modification date: 2023-08-09)

• Primary citation: Jadhav, P.K.,Woerner, F.J.,Lam, P.Y.,Hodge, C.N.,Eyermann, C.J.,Man, H.W.,Daneker, W.F.,Bacheler, L.T.,Rayner, M.M.,Meek, J.L.,Erickson-Viitanen, S.,Jackson, D.A.,Calabrese, J.C.,Schadt, M.,Chang, C.H.; Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.; J.Med.Chem., 41:1446-1455, 1998; PubMed: 9554878; DOI: 10.1021/jm970524i

Experimental method

X-RAY DIFFRACTION (1.8 Å)