1QBR

HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY

Summary for 1QBR

Entry DOI	10.2210/pdb1qbr/pdb
Descriptor	HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-3,3'-[[TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-D IYL] BIS(METHYLENE)]BIS[N-2-THIAZOLYLBENZAMIDE] (2 entities in total)
Functional Keywords	hydrolase (acid proteinase), aspartyl protease
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains	2
Total formula weight	22274.24
Authors	Ala, P.,Chang, C.-H. (deposition date: 1997-04-25, release date: 1997-10-15, Last modification date: 2024-02-14)
Primary citation	Jadhav, P.K.,Ala, P.,Woerner, F.J.,Chang, C.H.,Garber, S.S.,Anton, E.D.,Bacheler, L.T. Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV. J.Med.Chem., 40:181-191, 1997 Cited by PubMed: 9003516 DOI: 10.1021/jm960586t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation