8T1F

Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047

Summary for 8T1F

Entry DOI	10.2210/pdb8t1f/pdb
Related	8T1B 8T1C 8T1D 8T1E
EMDB information	40958 40959 40960 40961 40962
Descriptor	Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (3 entities in total)
Functional Keywords	transient receptor potential v family member 4, trp, channel, trpv4, trp channels, membrane protein, antagonist, inhibited state, hc-067047
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	515798.12
Authors	Talyzina, I.A.,Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-06-02, release date: 2023-07-05)
Primary citation	Nadezhdin, K.D.,Talyzina, I.A.,Parthasarathy, A.,Neuberger, A.,Zhang, D.X.,Sobolevsky, A.I. Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14:3733-3733, 2023 Cited by PubMed: 37353478 DOI: 10.1038/s41467-023-39346-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.49 Å)

Structure validation