8T1B

Cryo-EM structure of full-length human TRPV4 in apo state

Summary for 8T1B

Entry DOI	10.2210/pdb8t1b/pdb
EMDB information	40958
Descriptor	Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, [(2~{R})-2-[(~{Z})-hexadec-9-enoyl]oxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (~{Z})-docos-13-enoate, (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, ... (5 entities in total)
Functional Keywords	transient receptor potential v family member 4, trp, channel, trpv4, trp channels, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	552893.23
Authors	Nadezhdin, K.D.,Talyzina, I.A.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-06-02, release date: 2023-07-05)
Primary citation	Nadezhdin, K.D.,Talyzina, I.A.,Parthasarathy, A.,Neuberger, A.,Zhang, D.X.,Sobolevsky, A.I. Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14:3733-3733, 2023 Cited by PubMed: 37353478 DOI: 10.1038/s41467-023-39346-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation