8T1E

Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD

Summary for 8T1E

• Entry DOI: 10.2210/pdb8t1e/pdb
• Related: 8T1B 8T1C 8T1D
• EMDB information: 40958 40959 40960 40961
• Descriptor: Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, [(2~{R})-2-[(~{Z})-hexadec-9-enoyl]oxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (~{Z})-docos-13-enoate, (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, ... (5 entities in total)
• Functional Keywords: transient receptor potential v family member 4, trp, channel, trpv4, trp channels, membrane protein, agonist, 4a-pdd, 4alpha-phorbol 12, 13-didecanoate, closed state
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 546348.84

Authors

Talyzina, I.A.,Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-06-02, release date: 2023-07-05)

• Primary citation: Nadezhdin, K.D.,Talyzina, I.A.,Parthasarathy, A.,Neuberger, A.,Zhang, D.X.,Sobolevsky, A.I.; Structure of human TRPV4 in complex with GTPase RhoA.; Nat Commun, 14:3733-3733, 2023; PubMed: 37353478; DOI: 10.1038/s41467-023-39346-z

Experimental method

ELECTRON MICROSCOPY (2.77 Å)