5UQ3
Crystal structure of human Cdk2-Spy1-P27 ternary complex
Summary for 5UQ3
Entry DOI | 10.2210/pdb5uq3/pdb |
Related | 5UQ1 5UQ2 |
Descriptor | Cyclin-dependent kinase 2, Speedy protein A, Cyclin-dependent kinase inhibitor 1B (3 entities in total) |
Functional Keywords | phosphotransferase, protein kinase, cell cycle regulation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : Q5MJ70 P46527 |
Total number of polymer chains | 3 |
Total formula weight | 76063.71 |
Authors | McGrath, D.A.,Tripathi, S.M.,Rubin, S.M. (deposition date: 2017-02-06, release date: 2017-07-05, Last modification date: 2017-08-09) |
Primary citation | McGrath, D.A.,Fifield, B.A.,Marceau, A.H.,Tripathi, S.,Porter, L.A.,Rubin, S.M. Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36:2251-2262, 2017 Cited by PubMed: 28666995DOI: 10.15252/embj.201796905 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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