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5UQ3

Crystal structure of human Cdk2-Spy1-P27 ternary complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000086biological_processG2/M transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000287molecular_functionmagnesium ion binding
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000781cellular_componentchromosome, telomeric region
A0000793cellular_componentcondensed chromosome
A0000805cellular_componentX chromosome
A0000806cellular_componentY chromosome
A0001673cellular_componentmale germ cell nucleus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006338biological_processchromatin remodeling
A0006351biological_processDNA-templated transcription
A0006468biological_processprotein phosphorylation
A0006813biological_processpotassium ion transport
A0007099biological_processcentriole replication
A0007165biological_processsignal transduction
A0007265biological_processRas protein signal transduction
A0007346biological_processregulation of mitotic cell cycle
A0008284biological_processpositive regulation of cell population proliferation
A0010033biological_processresponse to organic substance
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010468biological_processregulation of gene expression
A0015030cellular_componentCajal body
A0016301molecular_functionkinase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019904molecular_functionprotein domain specific binding
A0030332molecular_functioncyclin binding
A0031453biological_processpositive regulation of heterochromatin formation
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0032298biological_processpositive regulation of DNA-templated DNA replication initiation
A0035173molecular_functionhistone kinase activity
A0043247biological_processtelomere maintenance in response to DNA damage
A0043687biological_processpost-translational protein modification
A0045740biological_processpositive regulation of DNA replication
A0045893biological_processpositive regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0051298biological_processcentrosome duplication
A0051301biological_processcell division
A0051321biological_processmeiotic cell cycle
A0071732biological_processcellular response to nitric oxide
A0090398biological_processcellular senescence
A0097123cellular_componentcyclin A1-CDK2 complex
A0097124cellular_componentcyclin A2-CDK2 complex
A0097134cellular_componentcyclin E1-CDK2 complex
A0097135cellular_componentcyclin E2-CDK2 complex
A0097472molecular_functioncyclin-dependent protein kinase activity
A0106310molecular_functionprotein serine kinase activity
A1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
B0019901molecular_functionprotein kinase binding
B0045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
C0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
C0000082biological_processG1/S transition of mitotic cell cycle
C0001666biological_processresponse to hypoxia
C0001890biological_processplacenta development
C0001934biological_processpositive regulation of protein phosphorylation
C0004860molecular_functionprotein kinase inhibitor activity
C0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005829cellular_componentcytosol
C0006813biological_processpotassium ion transport
C0006915biological_processapoptotic process
C0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
C0007096biological_processregulation of exit from mitosis
C0007219biological_processNotch signaling pathway
C0007346biological_processregulation of mitotic cell cycle
C0007507biological_processheart development
C0007605biological_processsensory perception of sound
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0009749biological_processresponse to glucose
C0014070biological_processresponse to organic cyclic compound
C0019901molecular_functionprotein kinase binding
C0019903molecular_functionprotein phosphatase binding
C0019914molecular_functioncyclin-dependent protein kinase activating kinase regulator activity
C0030308biological_processnegative regulation of cell growth
C0030332molecular_functioncyclin binding
C0030334biological_processregulation of cell migration
C0030544molecular_functionHsp70 protein binding
C0031116biological_processpositive regulation of microtubule polymerization
C0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
C0031625molecular_functionubiquitin protein ligase binding
C0032355biological_processresponse to estradiol
C0032991cellular_componentprotein-containing complex
C0033673biological_processnegative regulation of kinase activity
C0042326biological_processnegative regulation of phosphorylation
C0043200biological_processresponse to amino acid
C0043231cellular_componentintracellular membrane-bounded organelle
C0043434biological_processresponse to peptide hormone
C0044877molecular_functionprotein-containing complex binding
C0045732biological_processpositive regulation of protein catabolic process
C0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
C0045740biological_processpositive regulation of DNA replication
C0045892biological_processnegative regulation of DNA-templated transcription
C0045930biological_processnegative regulation of mitotic cell cycle
C0046686biological_processresponse to cadmium ion
C0048102biological_processautophagic cell death
C0048839biological_processinner ear development
C0050680biological_processnegative regulation of epithelial cell proliferation
C0051087molecular_functionprotein-folding chaperone binding
C0051168biological_processnuclear export
C0051726biological_processregulation of cell cycle
C0060090molecular_functionmolecular adaptor activity
C0060767biological_processepithelial cell proliferation involved in prostate gland development
C0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
C0071236biological_processcellular response to antibiotic
C0071285biological_processcellular response to lithium ion
C0071407biological_processcellular response to organic cyclic compound
C0071456biological_processcellular response to hypoxia
C0090398biological_processcellular senescence
C0140678molecular_functionmolecular function inhibitor activity
C1902746biological_processregulation of lens fiber cell differentiation
C1902806biological_processregulation of cell cycle G1/S phase transition
C1904019biological_processepithelial cell apoptotic process
C1904030biological_processnegative regulation of cyclin-dependent protein kinase activity
C1904036biological_processnegative regulation of epithelial cell apoptotic process
C1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
C1905179biological_processnegative regulation of cardiac muscle tissue regeneration
C1990757molecular_functionubiquitin ligase activator activity
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
ChainResidueDetails
AILE10-LYS33

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
AVAL123-ILE135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine; by UHMK1 => ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:12093740, ECO:0000269|PubMed:14504289, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER516

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:17254967
ChainResidueDetails
ALYS33
AGLU81
AASP86
ALYS129
CTYR580

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
ChainResidueDetails
CTYR594
AASP145

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:16195327
ChainResidueDetails
ALYS88
ALEU166
CTYR595

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK1, PKB/AKT1 and PIM1 => ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:12244303, ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:23707388
ChainResidueDetails
CTHR663

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P46414
ChainResidueDetails
CTHR676

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1, CDK1 and CDK2 => ECO:0000269|PubMed:10323868, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:16209941, ECO:0000269|PubMed:23478441
ChainResidueDetails
CTHR693

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK1, PKB/AKT1, RPS6KA1, RPS6KA3 and PIM1 => ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:14504289, ECO:0000269|PubMed:15280662, ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:23707388
ChainResidueDetails
CTHR704

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR19

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
ChainResidueDetails
ATHR160

219869

PDB entries from 2024-05-15

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