5UQ3

Crystal structure of human Cdk2-Spy1-P27 ternary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 2	polymer	301	34309.8	1	UniProt (P24941) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 2,p33 protein kinase
2	B	Speedy protein A	polymer	160	19312.2	1	UniProt (Q5MJ70) Pfam (PF11357) In PDB	Homo sapiens (Human)	Rapid inducer of G2/M progression in oocytes A,hSpy/Ringo A,Speedy-1,Spy1
3	C	Cyclin-dependent kinase inhibitor 1B	polymer	201	22441.7	1	UniProt (P46527) Pfam (PF02234) In PDB	Homo sapiens (Human)	Cyclin-dependent kinase inhibitor p27,p27Kip1

Sequence modifications

A: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

B: 61 - 213 (UniProt: Q5MJ70)

PDB	External Database	Details
Gly 54	-	expression tag
Ala 55	-	expression tag
Met 56	-	expression tag
Asp 57	-	expression tag
Pro 58	-	expression tag
Glu 59	-	expression tag
Phe 60	-	expression tag

C: 507 - 704 (UniProt: P46527)

PDB	External Database	Details
Gly 504	-	expression tag
Glu 505	-	expression tag
Phe 506	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	76063.7
All*	Total formula weight	76063.7

*Water molecules are not included.