4JQG

Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom.

Summary for 4JQG

Entry DOI	10.2210/pdb4jqg/pdb
Related	2OW0 2OW1 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JXA
Descriptor	fluorogenic peptidic substrate (8MC)PLG(PFF)(DNW)AR(NH2), SODIUM ION, Matrix metalloproteinase-9, ... (11 entities in total)
Functional Keywords	halogen-water-hydrogen bridge, zincin-like, gelatinase, collagenase, catalytic domain, hydrolase-substrate complex, hydrolase/substrate
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space, extracellular matrix : P14780
Total number of polymer chains	4
Total formula weight	40327.38
Authors	Stura, E.A.,Vera, L.,Cassar-Lajeunesse, E.,Tranchant, I.,Amoura, M.,Dive, V. (deposition date: 2013-03-20, release date: 2014-03-12, Last modification date: 2023-12-06)
Primary citation	Tranchant, I.,Vera, L.,Czarny, B.,Amoura, M.,Cassar, E.,Beau, F.,Stura, E.A.,Dive, V. Halogen Bonding Controls Selectivity of FRET Substrate Probes for MMP-9. Chem.Biol., 21:408-413, 2014 Cited by PubMed: 24583051 DOI: 10.1016/j.chembiol.2014.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.849 Å)

Structure validation