4JBX
Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with SK-78
Summary for 4JBX
Entry DOI | 10.2210/pdb4jbx/pdb |
Related | 1E2P 3F0T 3RDP 4IVP 4IVQ 4IVR 4JBY |
Descriptor | Thymidine kinase, 6-[3-hydroxy-2-(hydroxymethyl)prop-1-en-1-yl]-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, SULFATE ION, ... (5 entities in total) |
Functional Keywords | dna synthesis, pet imaging tracer, atp binding, nucleotide binding, transferase |
Biological source | Human herpesvirus 1 (HHV-1) |
Total number of polymer chains | 2 |
Total formula weight | 72907.44 |
Authors | Pernot, L.,Novakovic, I.,Westermaier, Y.,Perozzo, R.,Raic-Malic, S.,Scapozza, L. (deposition date: 2013-02-20, release date: 2013-03-06, Last modification date: 2023-09-20) |
Primary citation | Pernot, L.,Novakovic, I.,Perozzo, R.,Raic-Malic, S.,Scapozza, L. New thymine derivatives as HSV1-TK ligand for the development of PET imaging tracer To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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