4IVR

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with IN52/10

Summary for 4IVR

• Entry DOI: 10.2210/pdb4ivr/pdb
• Related: 1E2P 3F0T 3RDP 4IVP 4IVQ
• Descriptor: Thymidine kinase, 2-[(2,6-dimethoxy-5-methylpyrimidin-4-yl)methylidene]propane-1,3-diol, SULFATE ION, ... (4 entities in total)
• Functional Keywords: dna synthesis, pet imaging tracer, atp binding, nucleotide binding, transferase
• Biological source: Human herpesvirus 1 (HHV-1)
• Total number of polymer chains: 2
• Total formula weight: 72230.81

Authors

Pernot, L.,Novakovic, I.,Westermaier, Y.,Perozzo, R.,Raic-Malic, S.,Scapozza, L. (deposition date: 2013-01-23, release date: 2013-02-06, Last modification date: 2023-09-20)

• Primary citation: Pernot, L.,Novakovic, I.,Perozzo, R.,Raic-Malic, S.,Scapozza, L.; New thymine derivatives as HSV1-TK ligand for the development of PET imaging tracer; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)