3RDP

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT

Summary for 3RDP

Entry DOI	10.2210/pdb3rdp/pdb
Related	1E2H 1E2P 3F0T
Descriptor	Thymidine kinase, SULFATE ION, 6-[(2R)-2-(fluoromethyl)-3-hydroxy-propyl]-1,5-dimethyl-pyrimidine-2,4-dione, ... (4 entities in total)
Functional Keywords	transferase, thymidine kinase, dna-synthesis, pet tracer, atp-binding, dna synthesis, early protein, nucleotide-binding
Biological source	Human herpesvirus 1 (HHV-1)
Total number of polymer chains	2
Total formula weight	72306.83
Authors	Pernot, L.,Perozzo, R.,Westermaier, Y.,Martic, M.,Ametamey, S.,Scapozza, L. (deposition date: 2011-04-01, release date: 2011-08-03, Last modification date: 2023-11-01)
Primary citation	Martic, M.,Pernot, L.,Westermaier, Y.,Perozzo, R.,Kraljevic, T.G.,Kristafor, S.,Raic-Malic, S.,Scapozza, L.,Ametamey, S. Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids, 30:293-315, 2011 Cited by PubMed: 21623543 DOI: 10.1080/15257770.2011.581258 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation