4AYE
Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant
Summary for 4AYE
Entry DOI | 10.2210/pdb4aye/pdb |
Related | 1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2G7I 2JGW 2JGX 2UWN 2V8E 2W80 2W81 2WII 2XQW 2Y7S 4AYD |
Descriptor | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | immune system, antigens, bacterial proteins, vaccines |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted: P08603 |
Total number of polymer chains | 6 |
Total formula weight | 127161.72 |
Authors | Johnson, S.,Tan, L.,van der Veen, S.,Caesar, J.,Goicoechea De Jorge, E.,Everett, R.J.,Bai, X.,Exley, R.M.,Ward, P.N.,Ruivo, N.,Trivedi, K.,Cumber, E.,Jones, R.,Newham, L.,Staunton, D.,Borrow, R.,Pickering, M.,Lea, S.M.,Tang, C.M. (deposition date: 2012-06-20, release date: 2012-11-07, Last modification date: 2023-12-20) |
Primary citation | Johnson, S.,Tan, L.,Van Der Veen, S.,Caesar, J.,Goicoechea De Jorge, E.,Harding, R.J.,Bai, X.,Exley, R.M.,Ward, P.N.,Ruivo, N.,Trivedi, K.,Cumber, E.,Jones, R.,Newham, L.,Staunton, D.,Ufret-Vincenty, R.,Borrow, R.,Pickering, M.C.,Lea, S.M.,Tang, C.M. Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules. Plos Pathog., 8:2981-, 2012 Cited by PubMed: 23133374DOI: 10.1371/JOURNAL.PPAT.1002981 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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