2W80

Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H

Summary for 2W80

• Entry DOI: 10.2210/pdb2w80/pdb
• Related: 1FHC 1HAQ 1HFH 1KOV 2G7I 2JGW 2JGX 2UWN 2V8E
• Descriptor: COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN (3 entities in total)
• Functional Keywords: glycoprotein, immune evasion, age-related macular degeneration, innate immunity, immune response, disease mutation, factor h, complement alternate pathway, vaccine candidate, immune system
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P08603
• Total number of polymer chains: 8
• Total formula weight: 164820.42

Authors

Schneider, M.C.,Prosser, B.E.,Caesar, J.J.E.,Kugelberg, E.,Li, S.,Zhang, Q.,Quoraishi, S.,Lovett, J.E.,Deane, J.E.,Sim, R.B.,Roversi, P.,Johnson, S.,Tang, C.M.,Lea, S.M. (deposition date: 2009-01-08, release date: 2009-03-03, Last modification date: 2023-12-13)

• Primary citation: Schneider, M.C.,Prosser, B.E.,Caesar, J.J.E.,Kugelberg, E.,Li, S.,Zhang, Q.,Quoraishi, S.,Lovett, J.E.,Deane, J.E.,Sim, R.B.,Roversi, P.,Johnson, S.,Tang, C.M.,Lea, S.M.; Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.; Nature, 458:890-, 2009; PubMed: 19225461; DOI: 10.1038/NATURE07769

Experimental method

X-RAY DIFFRACTION (2.35 Å)