2G7I

Structure of Human Complement Factor H Carboxyl Terminal Domains 19-20: a Basis for Atypical Hemolytic Uremic Syndrome

Summary for 2G7I

Entry DOI	10.2210/pdb2g7i/pdb
Descriptor	Complement factor H (2 entities in total)
Functional Keywords	sushi (ccp/scr) domain, complement, regulator, factor h, beta-1h globulin, immune system, atypical hemolytic uremic syndrome, heparin binding
Biological source	Homo sapiens (human)
Cellular location	Secreted: P08603
Total number of polymer chains	1
Total formula weight	14297.31
Authors	Jaakola, V.-P.,Jokiranta, T.S.,Goldman, A. (deposition date: 2006-02-28, release date: 2006-05-23, Last modification date: 2011-07-13)
Primary citation	Jokiranta, T.S.,Jaakola, V.-P.,Lehtinen, M.J.,Parepalo, M.,Meri, S.,Goldman, A. Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. Embo J., 25:1784-1794, 2006 Cited by PubMed: 16601698 DOI: 10.1038/sj.emboj.7601052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation