2XQW

Structure of Factor H domains 19-20 in complex with complement C3d

Summary for 2XQW

Entry DOI	10.2210/pdb2xqw/pdb
Related	1C3D 1FHC 1GHQ 1HAQ 1HCC 1HFH 1HFI 1KOV 1W2S 2A73 2A74 2G7I 2HR0 2JGW 2JGX 2UWN 2V8E 2W80 2W81 2WII 2WIN 2WY7 2WY8 2XWB 2XWJ
Descriptor	COMPLEMENT C3, COMPLEMENT FACTOR H (3 entities in total)
Functional Keywords	immune system, complement alternative pathway, atypical hemolytic uremic syndrome, ahus, cfh, fh, c3b
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	3
Total formula weight	80781.56
Authors	Kajander, T.,Lehtinen, M.J.,Hyvarinen, S.,Bhattacharjee, A.,Leung, E.,Isenman, D.E.,Meri, S.,Jokiranta, T.S.,Goldman, A. (deposition date: 2010-09-07, release date: 2011-02-02, Last modification date: 2023-12-20)
Primary citation	Kajander, T.,Lehtinen, M.J.,Hyvarinen, S.,Bhattacharjee, A.,Leung, E.,Isenman, D.E.,Meri, S.,Goldman, A.,Jokiranta, T.S. Dual Interaction of Factor H with C3D and Glycosaminoglycans in Host-Nonhost Discrimination by Complement. Proc.Natl.Acad.Sci.USA, 108:2897-, 2011 Cited by PubMed: 21285368 DOI: 10.1073/PNAS.1017087108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.306 Å)

Structure validation