4A9H

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

Summary for 4A9H

Entry DOI	10.2210/pdb4a9h/pdb
Related	1X0J 2YDW 2YEK 4A9E 4A9F 4A9I 4A9J 4A9K 4A9L 4A9M 4A9N 4A9O 4A9P
Descriptor	BROMODOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, (2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE, ... (5 entities in total)
Functional Keywords	signaling protein, inhibitor, histone, epigenetic reader
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	3
Total formula weight	54610.20
Authors	Chung, C.W.,Bamborough, P. (deposition date: 2011-11-26, release date: 2012-01-11, Last modification date: 2019-05-15)
Primary citation	Chung, C.W.,Dean, T.W.,Woolven, J.M.,Bamborough, P. Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55:576-, 2012 Cited by PubMed: 22136404 DOI: 10.1021/JM201320W PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation