2YEK
Crystal Structure of the First Bromodomain of Human Brd2 with the inhibitor GSK525762 (IBET)
Summary for 2YEK
Entry DOI | 10.2210/pdb2yek/pdb |
Related | 1X0J 2YDW 2YEL 2YEM |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 2, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | signaling protein, histone, epigenetic reader |
Biological source | HOMO SAPIENS |
Cellular location | Nucleus (Probable): P25440 |
Total number of polymer chains | 3 |
Total formula weight | 54706.39 |
Authors | Chung, C.W. (deposition date: 2011-03-25, release date: 2011-06-15, Last modification date: 2012-11-21) |
Primary citation | Chung, C.W.,Coste, H.,White, J.H.,Mirguet, O.,Wilde, J.,Gosmini, R.L.,Delves, C.,Magny, S.M.,Woodward, R.,Hughes, S.A.,Boursier, E.V.,Flynn, H.,Bouillot, A.M.,Bamborough, P.,Brusq, J.M.,Gellibert, F.J.,Jones, E.J.,Riou, A.M.,Homes, P.,Martin, S.L.,Uings, I.J.,Toum, J.,Clement, C.A.,Boullay, A.B.,Grimley, R.L.,Blandel, F.M.,Prinjha, R.K.,Lee, K.,Kirilovsky, J.,Nicodeme, E. Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains. J.Med.Chem., 54:3827-, 2011 Cited by PubMed: 21568322DOI: 10.1021/JM200108T PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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