4A9M

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-cyclopentyl-5-(3,5- dimethyl-1,2-oxazol-4-yl)-2-methylbenzene-1-sulfonamide

Summary for 4A9M

• Entry DOI: 10.2210/pdb4a9m/pdb
• Related: 1X0J 2YDW 2YEK 4A9E 4A9F 4A9I 4A9J
• Descriptor: BROMODOMAIN CONTAINING 2, N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methylbenzenesulfonamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, histone, epigenetic reader, signaling protein
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus (By similarity): P25440
• Total number of polymer chains: 3
• Total formula weight: 55017.67

Authors

Chung, C.,Bamborough, P. (deposition date: 2011-11-26, release date: 2012-02-08)

• Primary citation: Bamborough, P.,Diallo, H.,Goodacre, J.D.,Gordon, L.,Lewis, A.,Seal, J.T.,Wilson, D.M.,Woodrow, M.D.,Chung, C.W.; Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides.; J.Med.Chem., 55:587-, 2012; PubMed: 22136469; DOI: 10.1021/JM201283Q

Experimental method

X-RAY DIFFRACTION (2.06 Å)