3RN2
Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors
Summary for 3RN2
Entry DOI | 10.2210/pdb3rn2/pdb |
Related | 3RLN 3RLO 3RN5 3RNU |
Descriptor | Interferon-inducible protein AIM2, DNA (5'-D(*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*TP*CP*TP*TP*TP*GP*AP*TP*GP*G)-3'), 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | cytosolic dna sensor, inflammasome, dna binding, cytosolic, immune system-dna complex, immune system/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14862 |
Total number of polymer chains | 4 |
Total formula weight | 59599.32 |
Authors | |
Primary citation | Jin, T.,Perry, A.,Jiang, J.,Smith, P.,Curry, J.A.,Unterholzner, L.,Jiang, Z.,Horvath, G.,Rathinam, V.A.,Johnstone, R.W.,Hornung, V.,Latz, E.,Bowie, A.G.,Fitzgerald, K.A.,Xiao, T.S. Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor. Immunity, 36:561-571, 2012 Cited by PubMed: 22483801DOI: 10.1016/j.immuni.2012.02.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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