3RLN

Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors

Summary for 3RLN

• Entry DOI: 10.2210/pdb3rln/pdb
• Related: 3RLO 3RN2 3RN5 3RNU
• Descriptor: Gamma-interferon-inducible protein 16 (2 entities in total)
• Functional Keywords: hin200/ob fold/dna binding, cytosolic dna sensor/dna binding, dna, cytosol, dna binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q16666
• Total number of polymer chains: 1
• Total formula weight: 22408.72

Authors

Jin, T.C.,Xiao, T. (deposition date: 2011-04-19, release date: 2012-04-25, Last modification date: 2023-09-13)

• Primary citation: Jin, T.,Perry, A.,Jiang, J.,Smith, P.,Curry, J.A.,Unterholzner, L.,Jiang, Z.,Horvath, G.,Rathinam, V.A.,Johnstone, R.W.,Hornung, V.,Latz, E.,Bowie, A.G.,Fitzgerald, K.A.,Xiao, T.S.; Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.; Immunity, 36:561-571, 2012; PubMed: 22483801; DOI: 10.1016/j.immuni.2012.02.014

Experimental method

X-RAY DIFFRACTION (2.251 Å)