3KJ2
Mcl-1 in complex with Bim BH3 mutant F4aE
Summary for 3KJ2
Entry DOI | 10.2210/pdb3kj2/pdb |
Related | 2PQK 3KJ0 3KJ2 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION, ... (5 entities in total) |
Functional Keywords | bcl-2, bh3, apoptosis, protein-peptide complex, alternative splicing, cytoplasm, developmental protein, differentiation, isopeptide bond, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521 |
Total number of polymer chains | 2 |
Total formula weight | 21040.11 |
Authors | Fire, E.,Grant, R.A.,Keating, A.E. (deposition date: 2009-11-02, release date: 2010-02-16, Last modification date: 2021-10-13) |
Primary citation | Fire, E.,Gulla, S.V.,Grant, R.A.,Keating, A.E. Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19:507-519, 2010 Cited by PubMed: 20066663DOI: 10.1002/pro.329 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.351 Å) |
Structure validation
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