3KJ0

Mcl-1 in complex with Bim BH3 mutant I2dY

Summary for 3KJ0

• Entry DOI: 10.2210/pdb3kj0/pdb
• Related: 2PQK 3KJ1 3KJ2
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• Functional Keywords: bcl-2, bh3, apoptosis, protein-peptide complex, alternative splicing, cytoplasm, developmental protein, differentiation, isopeptide bond, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass membrane protein (Potential): Q07820; Endomembrane system; Peripheral membrane protein (By similarity). Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• Total number of polymer chains: 2
• Total formula weight: 21238.97

Authors

Fire, E.,Grant, R.A.,Keating, A.E. (deposition date: 2009-11-02, release date: 2010-02-16, Last modification date: 2024-02-21)

• Primary citation: Fire, E.,Gulla, S.V.,Grant, R.A.,Keating, A.E.; Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.; Protein Sci., 19:507-519, 2010; PubMed: 20066663; DOI: 10.1002/pro.329

Experimental method

X-RAY DIFFRACTION (1.7 Å)