2PQK
X-ray crystal structure of human Mcl-1 in complex with Bim BH3
Summary for 2PQK
Entry DOI | 10.2210/pdb2pqk/pdb |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Bim BH3 peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | bcl-2 family, bh3 domain, apoptosis |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 |
Total number of polymer chains | 2 |
Total formula weight | 21542.35 |
Authors | Bare, E.,Grant, R.A.,Keating, A.E. (deposition date: 2007-05-02, release date: 2007-06-19, Last modification date: 2017-10-18) |
Primary citation | Fire, E.,Gulla, S.V.,Grant, R.A.,Keating, A.E. Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19:507-519, 2010 Cited by PubMed: 20066663DOI: 10.1002/pro.329 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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