3KJ2
Mcl-1 in complex with Bim BH3 mutant F4aE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 158 | 17937.4 | 1 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl-2-like protein 3, Bcl2-L-3 |
| 2 | B | Bcl-2-like protein 11 | polymer | 22 | 2782.1 | 1 | UniProt (O43521) Pfam (PF08945) In PDB | Homo sapiens (human) | Bcl2-L-11, Bcl2-interacting mediator of cell death |
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 172 - 327 (UniProt: Q07820)
B: 1 - 21 (UniProt: O43521)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 17 | Phe 159 | engineered mutation |
| Arg 22 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20719.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 320.7 | |
| All* | Total formula weight | 21040.1 |
