3E1Z

Crystal structure of the parasite protesase inhibitor chagasin in complex with papain

Summary for 3E1Z

• Entry DOI: 10.2210/pdb3e1z/pdb
• Related: 1KHQ 1ME3 2NQD 2OUL 3CBJ 3CBK
• Descriptor: Chagasin, Papain, ZINC ION, ... (6 entities in total)
• Functional Keywords: chagasin-papain complex, papain, chagas disease, cysteine proteinases, protein inhibitors, cytoplasmic vesicle, protease inhibitor, thiol protease inhibitor, allergen, hydrolase, protease, thiol protease, zymogen, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
• Biological source: Trypanosoma cruzi; More
• Cellular location: Flagellar pocket: Q966X9
• Total number of polymer chains: 2
• Total formula weight: 36092.49

Authors

Redzynia, I.,Bujacz, G.,Bujacz, A.,Ljunggren, A.,Abrahamson, M.,Jaskolski, M. (deposition date: 2008-08-05, release date: 2009-01-27, Last modification date: 2023-11-01)

• Primary citation: Redzynia, I.,Ljunggren, A.,Bujacz, A.,Abrahamson, M.,Jaskolski, M.,Bujacz, G.; Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.; Febs J., 276:793-806, 2009; PubMed: 19143838; DOI: 10.1111/j.1742-4658.2008.06824.x

Experimental method

X-RAY DIFFRACTION (1.86 Å)