2OUL
The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family
Summary for 2OUL
Entry DOI | 10.2210/pdb2oul/pdb |
Related | 1YVB |
Descriptor | Falcipain 2, Chagasin (3 entities in total) |
Functional Keywords | cysteine protease, inhibitor, macromolecular interaction, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum More |
Total number of polymer chains | 2 |
Total formula weight | 39241.15 |
Authors | Wang, S.X.,Chand, K.,Huang, R.,Whisstock, J.,Jacobelli, J.,Fletterick, R.J.,Rosenthal, P.J.,McKerrow, J.H. (deposition date: 2007-02-11, release date: 2008-02-26, Last modification date: 2023-08-30) |
Primary citation | Wang, S.X.,Pandey, K.C.,Scharfstein, J.,Whisstock, J.,Huang, R.K.,Jacobelli, J.,Fletterick, R.J.,Rosenthal, P.J.,Abrahamson, M.,Brinen, L.S.,Rossi, A.,Sali, A.,McKerrow, J.H. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure, 15:535-543, 2007 Cited by PubMed: 17502099DOI: 10.1016/j.str.2007.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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