3CBK
chagasin-cathepsin B
Summary for 3CBK
Entry DOI | 10.2210/pdb3cbk/pdb |
Related | 1HUC 2NNR 2NQD 3CBJ 3PBH |
Descriptor | Cathepsin B, Chagasin (3 entities in total) |
Functional Keywords | chagasin, cathepsin b, occluding loop, chagas disease, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen, cytoplasmic vesicle, protease inhibitor, thiol protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Lysosome : P07858 Flagellar pocket : Q966X9 |
Total number of polymer chains | 2 |
Total formula weight | 41366.10 |
Authors | Redzynia, I.,Bujacz, G.D.,Abrahamson, M.,Ljunggren, A.,Jaskolski, M.,Mort, J.S. (deposition date: 2008-02-22, release date: 2008-05-27, Last modification date: 2023-11-01) |
Primary citation | Redzynia, I.,Ljunggren, A.,Abrahamson, M.,Mort, J.S.,Krupa, J.C.,Jaskolski, M.,Bujacz, G. Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B. J.Biol.Chem., 283:22815-22825, 2008 Cited by PubMed: 18515357DOI: 10.1074/jbc.M802064200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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