3DPK
cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor
Summary for 3DPK
Entry DOI | 10.2210/pdb3dpk/pdb |
Related | 2i0v 2i1m 2ogv 3bea |
Descriptor | Macrophage colony-stimulating factor 1 receptor, Fibroblast growth factor receptor 1, SULFATE ION, 8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, ... (4 entities in total) |
Functional Keywords | receptor tyrosine kinase, kinase-inhibitor complex, atp-binding, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase, craniosynostosis, disease mutation, dwarfism, heparin-binding, kallmann syndrome |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P07333 |
Total number of polymer chains | 1 |
Total formula weight | 38843.26 |
Authors | Schubert, C. (deposition date: 2008-07-08, release date: 2009-02-17, Last modification date: 2023-08-30) |
Primary citation | Huang, H.,Hutta, D.A.,Rinker, J.M.,Hu, H.,Parsons, W.H.,Schubert, C.,DesJarlais, R.L.,Crysler, C.S.,Chaikin, M.A.,Donatelli, R.R.,Chen, Y.,Cheng, D.,Zhou, Z.,Yurkow, E.,Manthey, C.L.,Player, M.R. Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors J.Med.Chem., 52:1081-1099, 2009 Cited by PubMed: 19193011DOI: 10.1021/jm801406h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report