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2I1M

cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor

Summary for 2I1M
Entry DOI10.2210/pdb2i1m/pdb
Related2I0V 2I0Y
DescriptorMacrophage colony-stimulating factor 1 receptor, 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE (3 entities in total)
Functional Keywordskinase domain, kinase inhibitor complex, transferase
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Single-pass type I membrane protein: P07333
Total number of polymer chains1
Total formula weight37952.45
Authors
Schubert, C.,Schalk-Hihi, C. (deposition date: 2006-08-14, release date: 2006-11-28, Last modification date: 2024-02-21)
Primary citationSchubert, C.,Schalk-Hihi, C.,Struble, G.T.,Ma, H.C.,Petrounia, I.P.,Brandt, B.,Deckman, I.C.,Patch, R.J.,Player, M.R.,Spurlino, J.C.,Springer, B.A.
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
J.Biol.Chem., 282:4094-4101, 2007
Cited by
PubMed: 17132624
DOI: 10.1074/jbc.M608183200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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