2I0V

c-FMS tyrosine kinase in complex with a quinolone inhibitor

Summary for 2I0V

• Entry DOI: 10.2210/pdb2i0v/pdb
• Related: 2I0Y
• Descriptor: cFMS tyrosine kinase, SULFATE ION, 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE, ... (4 entities in total)
• Functional Keywords: receptor tyrosine kinase, kinase-inhibitor complex, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P07333
• Total number of polymer chains: 1
• Total formula weight: 38497.31

Authors

Schubert, C.,Schalk-Hihi, C. (deposition date: 2006-08-11, release date: 2006-11-28, Last modification date: 2024-02-21)

• Primary citation: Schubert, C.,Schalk-Hihi, C.,Struble, G.T.,Ma, H.C.,Petrounia, I.P.,Brandt, B.,Deckman, I.C.,Patch, R.J.,Player, M.R.,Spurlino, J.C.,Springer, B.A.; Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.; J.Biol.Chem., 282:4094-4101, 2007; PubMed: 17132624; DOI: 10.1074/jbc.M608183200

Experimental method

X-RAY DIFFRACTION (2.8 Å)