3BUW

Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk

Summary for 3BUW

Entry DOI	10.2210/pdb3buw/pdb
Related	3BUM 3BUN 3BUO 3BUX
Descriptor	13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL (3 entities in total)
Functional Keywords	cbl, tkb, ligase, signal transduction, proto-oncogene, complex, alternative splicing, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation, calcium, cytoplasm, metal-binding, ubl conjugation pathway, zinc, zinc-finger, ligase-signaling protein complex, ligase/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane : P43405 Cytoplasm: P22681
Total number of polymer chains	4
Total formula weight	79471.31
Authors	Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. (deposition date: 2008-01-03, release date: 2008-02-26, Last modification date: 2023-11-15)
Primary citation	Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27:804-816, 2008 Cited by PubMed: 18273061 DOI: 10.1038/emboj.2008.18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation