3BUO

Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'

Summary for 3BUO

Entry DOI	10.2210/pdb3buo/pdb
Related	3BUM 3BUN 3BUW 3BUX
Descriptor	13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL (3 entities in total)
Functional Keywords	cbl, tkb, ligase, signal transduction, proto-oncogene, complex, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, metal-binding, sh2 domain, ubl conjugation pathway, zinc-finger, ligase-signaling protein complex, ligase/signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	79491.18
Authors	Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. (deposition date: 2008-01-03, release date: 2008-02-26, Last modification date: 2023-11-15)
Primary citation	Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27:804-816, 2008 Cited by PubMed: 18273061 DOI: 10.1038/emboj.2008.18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation