3BUM

Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2

Summary for 3BUM

Entry DOI	10.2210/pdb3bum/pdb
Related	3BUN 3BUO 3BUW 3BUX
Descriptor	Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL (3 entities in total)
Functional Keywords	ligase, signal transduction, proto-oncogene, complex, cytoplasm, developmental protein, membrane, microtubule, polymorphism, calcium, metal-binding, phosphoprotein, sh2 domain, ubl conjugation pathway, zinc, zinc-finger
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	39766.65
Authors	Ng, C.,Jackson, A.R.,Buschdorf, P.J.,Sun, Q.,Guy, R.G.,Sivaraman, J. (deposition date: 2008-01-03, release date: 2008-02-26, Last modification date: 2023-11-15)
Primary citation	Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27:804-816, 2008 Cited by PubMed: 18273061 DOI: 10.1038/emboj.2008.18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation