3BUX

Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met

Summary for 3BUX

Entry DOI	10.2210/pdb3bux/pdb
Related	3BUM 3BUN 3BUO 3BUW
Descriptor	13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL (3 entities in total)
Functional Keywords	cbl, tkb, ligase, signal transduction, proto-oncogene, complex, atp-binding, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, calcium, cytoplasm, metal-binding, sh2 domain, ubl conjugation pathway, zinc, zinc-finger, ligase-signaling protein complex, ligase/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 Cytoplasm: P22681
Total number of polymer chains	4
Total formula weight	79575.25
Authors	Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. (deposition date: 2008-01-03, release date: 2008-02-26, Last modification date: 2023-11-15)
Primary citation	Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27:804-816, 2008 Cited by PubMed: 18273061 DOI: 10.1038/emboj.2008.18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation