3BAJ

Human Pancreatic Alpha-Amylase in Complex with Nitrate and Acarbose

Summary for 3BAJ

Entry DOI	10.2210/pdb3baj/pdb
Related	1BSI 1CPU 1HNY 2QMK 2QV4 3BAI 3BAK 3BAW 3BAX 3BAY
Descriptor	Pancreatic alpha-amylase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACARBOSE DERIVED PENTASACCHARIDE, ... (6 entities in total)
Functional Keywords	amylase, anion activation, human, pancreatic, enzyme, hydrolase, acarbose, transglycosylation, chloride, nitrate, carbohydrate metabolism, glycoprotein, glycosidase, metal-binding, pyrrolidone carboxylic acid, secreted
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	57062.34
Authors	Fredriksen, J.R.,Maurus, R.,Brayer, G.D. (deposition date: 2007-11-07, release date: 2008-03-25, Last modification date: 2023-08-30)
Primary citation	Maurus, R.,Begum, A.,Williams, L.K.,Fredriksen, J.R.,Zhang, R.,Withers, S.G.,Brayer, G.D. Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity Biochemistry, 47:3332-3344, 2008 Cited by PubMed: 18284212 DOI: 10.1021/bi701652t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation