1CPU
SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Summary for 1CPU
Entry DOI | 10.2210/pdb1cpu/pdb |
Related PRD ID | PRD_900001 |
Descriptor | PROTEIN (ALPHA-AMYLASE), 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | amylase, acarbose, glycosylation, mutagenesis, diabetes, catalysis, pancreatic, enzyme, human, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 57071.82 |
Authors | Brayer, G.D.,Sidhu, G.,Maurus, R.,Rydberg, E.H.,Braun, C.,Wang, Y.,Nguyen, N.T.,Overall, C.M.,Withers, S.G. (deposition date: 1999-06-07, release date: 1999-06-14, Last modification date: 2023-12-27) |
Primary citation | Brayer, G.D.,Sidhu, G.,Maurus, R.,Rydberg, E.H.,Braun, C.,Wang, Y.,Nguyen, N.T.,Overall, C.M.,Withers, S.G. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39:4778-4791, 2000 Cited by PubMed: 10769135DOI: 10.1021/bi9921182 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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