2QV4

Human pancreatic alpha-amylase complexed with nitrite and acarbose

Summary for 2QV4

• Entry DOI: 10.2210/pdb2qv4/pdb
• Related: 1BSI 1CPU 1HNY 2QMK
• Descriptor: Pancreatic alpha-amylase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: amylase, pichia pastoris, glycosylated protein, mutagenesis, diabetes, catalysis, pancreatic, enzyme, human, hydrolase, anion activation, nitrite, chloride, acarbose, transglycosylation, carbohydrate metabolism, glycoprotein, glycosidase, metal-binding, pyrrolidone carboxylic acid, secreted
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 57046.34

Authors

Williams, L.K.,Maurus, R.,Brayer, G.D. (deposition date: 2007-08-07, release date: 2008-03-25, Last modification date: 2023-08-30)

• Primary citation: Maurus, R.,Begum, A.,Williams, L.K.,Fredriksen, J.R.,Zhang, R.,Withers, S.G.,Brayer, G.D.; Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity; Biochemistry, 47:3332-3344, 2008; PubMed: 18284212; DOI: 10.1021/bi701652t

Experimental method

X-RAY DIFFRACTION (1.97 Å)