2PE2

CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 3-{5-[2-Oxo-5-ureido-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrol-3-yl}-N-(2-piperidin-1-yl-ethyl)-benzamide COMPLEX

Summary for 2PE2

Entry DOI	10.2210/pdb2pe2/pdb
Related	1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1Z5M 2PE0 2PE1
Descriptor	3-phosphoinositide-dependent protein kinase 1, SULFATE ION, 3-[5-({5-[(AMINOCARBONYL)AMINO]-2-OXO-2H-INDOL-3-YL}METHYL)-1H-PYRROL-3-YL]-N-(2-PIPERIDIN-1-YLETHYL)BENZAMIDE, ... (5 entities in total)
Functional Keywords	protein inhibitor complex, serine kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	34653.63
Authors	Whitlow, M.,Adler, M. (deposition date: 2007-04-01, release date: 2007-06-19, Last modification date: 2011-07-13)
Primary citation	Islam, I.,Brown, G.,Bryant, J.,Hrvatin, P.,Kochanny, M.J.,Phillips, G.B.,Yuan, S.,Adler, M.,Whitlow, M.,Lentz, D.,Polokoff, M.A.,Wu, J.,Shen, J.,Walters, J.,Ho, E.,Subramanyam, B.,Zhu, D.,Feldman, R.I.,Arnaiz, D.O. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517. Bioorg.Med.Chem.Lett., 17:3819-3825, 2007 Cited by PubMed: 17544272 DOI: 10.1016/j.bmcl.2007.05.060 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation