1GWR
HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE
Summary for 1GWR
Entry DOI | 10.2210/pdb1gwr/pdb |
Related | 1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1HCP 1HCQ 1QKT 1QKU 3ERD 3ERT |
Descriptor | OESTROGEN RECEPTOR, TRANSCRIPTION INTERMEDIARY FACTOR-2, ESTRADIOL, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, transactivation, agonist, af2 coactivator, receptor, activator, transcripti regulation, dna-binding, nuclear protein, zinc finger, ster binding, phosphorylation, polymorphism, alternative splicing |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 Nucleus: Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 58771.40 |
Authors | Pike, A.C.W.,Brzozowski, A.M. (deposition date: 2002-03-22, release date: 2002-08-29, Last modification date: 2023-12-13) |
Primary citation | Warnmark, A.,Treuter, E.,Gustafsson, J.-A.,Hubbard, R.E.,Brzozowski, A.M.,Pike, A.C.W. Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha. J.Biol.Chem., 277:21862-, 2002 Cited by PubMed: 11937504DOI: 10.1074/JBC.M200764200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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