1ERE

HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-ESTRADIOL

> Summary

Summary for 1ERE

DescriptorESTROGEN RECEPTOR, ESTRADIOL
Functional Keywordsnuclear receptor, transcription factor, steroid, agonist
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Nucleus. Isoform 3: Nucleus P03372
Total number of polymer chains6
Total molecular weight174969.43
Authors
Brzozowski, A.M.,Pike, A.C.W. (deposition date: 1997-09-08, release date: 1998-09-16, modification date: 2009-02-24)
Primary citation
Brzozowski, A.M.,Pike, A.C.,Dauter, Z.,Hubbard, R.E.,Bonn, T.,Engstrom, O.,Ohman, L.,Greene, G.L.,Gustafsson, J.A.,Carlquist, M.
Molecular basis of agonism and antagonism in the oestrogen receptor.
Nature, 389:753-758, 1997
PubMed: 9338790
DOI: 10.1038/39645
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21818011.9%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1ere
no rotation
Molmil generated image of 1ere
rotated about x axis by 90°
Molmil generated image of 1ere
rotated about y axis by 90°

> Structural details

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
A, B, C, D, E...ESTROGEN RECEPTORpolymer25328889.26
UniProt (P03372)
Pfam (PF00104)
Pfam (PF12743)
Homo sapiens (human)@PDBjESTROGEN RECEPTOR, ER-LBD, ER-ALPHA
ESTRADIOLnon-polymer272.46
waterwater18.0114

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains6
Total molecular weight173335.1
Non-Polymers*Number of molecules6
Total molecular weight1634.3
All*Total molecular weight174969.4
*Water molecules are not included.

> Experimental details

Refinement Statistics

Experimental method:X-RAY DIFFRACTION (3.1 Å)

Cell axes61.480115.160137.380
Cell angles90.0098.8090.00
SpacegroupP 1 21 1
Resolution limits20.00 - 3.10
the highest resolution shell value -
R-factor0.218*
R-work0.21800
R-free0.25100
RMSD bond length0.011
RMSD bond angle0.039

Data Collection Statistics

Resolution limits20.00 - 3.10
the highest resolution shell value -
Number of reflections33981
Rmerge_l_obs0.100*
Completeness99.1
Redundancy2.5
the highest resolution shell value2
I/sigma(I)-3

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit
1Vapor diffusion, hanging drop*8.118**

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
11dropprotein7-13 (mg/ml)
21reservoirTris-HCl0.1 (M)
31reservoirammonium formate2.4 (M)
41reservoirdimethylsulphoxide8 (%)
Annotated Information is extracted from Literature Info*

> Functional details

?

Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0016021cellular_componentintegral component of membrane
A0016020cellular_componentmembrane
A0005739cellular_componentmitochondrion
A0000790cellular_componentnuclear chromatin
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0043204cellular_componentperikaryon
A0048471cellular_componentperinuclear region of cytoplasm
A0005886cellular_componentplasma membrane
A0043234cellular_componentprotein complex
A0030315cellular_componentT-tubule
A0043195cellular_componentterminal bouton
A0035327cellular_componenttranscriptionally active chromatin
A0051117molecular_functionATPase binding
A0008013molecular_functionbeta-catenin binding
A0003682molecular_functionchromatin binding
A0001046molecular_functioncore promoter sequence-specific DNA binding
A0019899molecular_functionenzyme binding
A0030284molecular_functionestrogen receptor activity
A0034056molecular_functionestrogen response element binding
A0042562molecular_functionhormone binding
A0042802molecular_functionidentical protein binding
A0030235molecular_functionnitric-oxide synthase regulator activity
A0000978molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding
A0038052molecular_functionRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
A0005496molecular_functionsteroid binding
A0003707molecular_functionsteroid hormone receptor activity
A0003700molecular_functiontranscription factor activity, sequence-specific DNA binding
A0008134molecular_functiontranscription factor binding
A0001077molecular_functiontranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
A0008270molecular_functionzinc ion binding
A0008209biological_processandrogen metabolic process
A0001547biological_processantral ovarian follicle growth
A1990375biological_processbaculum development
A0071392biological_processcellular response to estradiol stimulus
A0006338biological_processchromatin remodeling
A0046697biological_processdecidualization
A0060750biological_processepithelial cell proliferation involved in mammary gland duct elongation
A0030520biological_processintracellular estrogen receptor signaling pathway
A0030518biological_processintracellular steroid hormone receptor signaling pathway
A0060749biological_processmammary gland alveolus development
A0060745biological_processmammary gland branching involved in pregnancy
A0010629biological_processnegative regulation of gene expression
A0046325biological_processnegative regulation of glucose import
A0043124biological_processnegative regulation of I-kappaB kinase/NF-kappaB signaling
A1901215biological_processnegative regulation of neuron death
A1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
A0043433biological_processnegative regulation of sequence-specific DNA binding transcription factor activity
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0000122biological_processnegative regulation of transcription from RNA polymerase II promoter
A0090209biological_processnegative regulation of triglyceride metabolic process
A0002076biological_processosteoblast development
A0007200biological_processphospholipase C-activating G-protein coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
A0050679biological_processpositive regulation of epithelial cell proliferation
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0048146biological_processpositive regulation of fibroblast proliferation
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0051000biological_processpositive regulation of nitric-oxide synthase activity
A0010863biological_processpositive regulation of phospholipase C activity
A0051091biological_processpositive regulation of sequence-specific DNA binding transcription factor activity
A0045944biological_processpositive regulation of transcription from RNA polymerase II promoter
A0045893biological_processpositive regulation of transcription, DNA-templated
A0060527biological_processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
A0060523biological_processprostate epithelial cord elongation
A0071168biological_processprotein localization to chromatin
A0060687biological_processregulation of branching involved in prostate gland morphogenesis
A0043523biological_processregulation of neuron apoptotic process
A0006355biological_processregulation of transcription, DNA-templated
A0032355biological_processresponse to estradiol
A0043627biological_processresponse to estrogen
A0060009biological_processSertoli cell development
A0060011biological_processSertoli cell proliferation
A0007165biological_processsignal transduction
A0006366biological_processtranscription from RNA polymerase II promoter
A0006367biological_processtranscription initiation from RNA polymerase II promoter
A0006351biological_processtranscription, DNA-templated
A0060065biological_processuterus development
A0060068biological_processvagina development
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0016021cellular_componentintegral component of membrane
B0016020cellular_componentmembrane
B0005739cellular_componentmitochondrion
B0000790cellular_componentnuclear chromatin
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0043204cellular_componentperikaryon
B0048471cellular_componentperinuclear region of cytoplasm
B0005886cellular_componentplasma membrane
B0043234cellular_componentprotein complex
B0030315cellular_componentT-tubule
B0043195cellular_componentterminal bouton
B0035327cellular_componenttranscriptionally active chromatin
B0051117molecular_functionATPase binding
B0008013molecular_functionbeta-catenin binding
B0003682molecular_functionchromatin binding
B0001046molecular_functioncore promoter sequence-specific DNA binding
B0019899molecular_functionenzyme binding
B0030284molecular_functionestrogen receptor activity
B0034056molecular_functionestrogen response element binding
B0042562molecular_functionhormone binding
B0042802molecular_functionidentical protein binding
B0030235molecular_functionnitric-oxide synthase regulator activity
B0000978molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding
B0038052molecular_functionRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
B0005496molecular_functionsteroid binding
B0003707molecular_functionsteroid hormone receptor activity
B0003700molecular_functiontranscription factor activity, sequence-specific DNA binding
B0008134molecular_functiontranscription factor binding
B0001077molecular_functiontranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
B0008270molecular_functionzinc ion binding
B0008209biological_processandrogen metabolic process
B0001547biological_processantral ovarian follicle growth
B1990375biological_processbaculum development
B0071392biological_processcellular response to estradiol stimulus
B0006338biological_processchromatin remodeling
B0046697biological_processdecidualization
B0060750biological_processepithelial cell proliferation involved in mammary gland duct elongation
B0030520biological_processintracellular estrogen receptor signaling pathway
B0030518biological_processintracellular steroid hormone receptor signaling pathway
B0060749biological_processmammary gland alveolus development
B0060745biological_processmammary gland branching involved in pregnancy
B0010629biological_processnegative regulation of gene expression
B0046325biological_processnegative regulation of glucose import
B0043124biological_processnegative regulation of I-kappaB kinase/NF-kappaB signaling
B1901215biological_processnegative regulation of neuron death
B1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
B0043433biological_processnegative regulation of sequence-specific DNA binding transcription factor activity
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0000122biological_processnegative regulation of transcription from RNA polymerase II promoter
B0090209biological_processnegative regulation of triglyceride metabolic process
B0002076biological_processosteoblast development
B0007200biological_processphospholipase C-activating G-protein coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
B0050679biological_processpositive regulation of epithelial cell proliferation
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0048146biological_processpositive regulation of fibroblast proliferation
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0051000biological_processpositive regulation of nitric-oxide synthase activity
B0010863biological_processpositive regulation of phospholipase C activity
B0051091biological_processpositive regulation of sequence-specific DNA binding transcription factor activity
B0045944biological_processpositive regulation of transcription from RNA polymerase II promoter
B0045893biological_processpositive regulation of transcription, DNA-templated
B0060527biological_processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
B0060523biological_processprostate epithelial cord elongation
B0071168biological_processprotein localization to chromatin
B0060687biological_processregulation of branching involved in prostate gland morphogenesis
B0043523biological_processregulation of neuron apoptotic process
B0006355biological_processregulation of transcription, DNA-templated
B0032355biological_processresponse to estradiol
B0043627biological_processresponse to estrogen
B0060009biological_processSertoli cell development
B0060011biological_processSertoli cell proliferation
B0007165biological_processsignal transduction
B0006366biological_processtranscription from RNA polymerase II promoter
B0006367biological_processtranscription initiation from RNA polymerase II promoter
B0006351biological_processtranscription, DNA-templated
B0060065biological_processuterus development
B0060068biological_processvagina development
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0016021cellular_componentintegral component of membrane
C0016020cellular_componentmembrane
C0005739cellular_componentmitochondrion
C0000790cellular_componentnuclear chromatin
C0005654cellular_componentnucleoplasm
C0005634cellular_componentnucleus
C0043204cellular_componentperikaryon
C0048471cellular_componentperinuclear region of cytoplasm
C0005886cellular_componentplasma membrane
C0043234cellular_componentprotein complex
C0030315cellular_componentT-tubule
C0043195cellular_componentterminal bouton
C0035327cellular_componenttranscriptionally active chromatin
C0051117molecular_functionATPase binding
C0008013molecular_functionbeta-catenin binding
C0003682molecular_functionchromatin binding
C0001046molecular_functioncore promoter sequence-specific DNA binding
C0019899molecular_functionenzyme binding
C0030284molecular_functionestrogen receptor activity
C0034056molecular_functionestrogen response element binding
C0042562molecular_functionhormone binding
C0042802molecular_functionidentical protein binding
C0030235molecular_functionnitric-oxide synthase regulator activity
C0000978molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding
C0038052molecular_functionRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
C0005496molecular_functionsteroid binding
C0003707molecular_functionsteroid hormone receptor activity
C0003700molecular_functiontranscription factor activity, sequence-specific DNA binding
C0008134molecular_functiontranscription factor binding
C0001077molecular_functiontranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
C0008270molecular_functionzinc ion binding
C0008209biological_processandrogen metabolic process
C0001547biological_processantral ovarian follicle growth
C1990375biological_processbaculum development
C0071392biological_processcellular response to estradiol stimulus
C0006338biological_processchromatin remodeling
C0046697biological_processdecidualization
C0060750biological_processepithelial cell proliferation involved in mammary gland duct elongation
C0030520biological_processintracellular estrogen receptor signaling pathway
C0030518biological_processintracellular steroid hormone receptor signaling pathway
C0060749biological_processmammary gland alveolus development
C0060745biological_processmammary gland branching involved in pregnancy
C0010629biological_processnegative regulation of gene expression
C0046325biological_processnegative regulation of glucose import
C0043124biological_processnegative regulation of I-kappaB kinase/NF-kappaB signaling
C1901215biological_processnegative regulation of neuron death
C1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
C0043433biological_processnegative regulation of sequence-specific DNA binding transcription factor activity
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0000122biological_processnegative regulation of transcription from RNA polymerase II promoter
C0090209biological_processnegative regulation of triglyceride metabolic process
C0002076biological_processosteoblast development
C0007200biological_processphospholipase C-activating G-protein coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0050679biological_processpositive regulation of epithelial cell proliferation
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0048146biological_processpositive regulation of fibroblast proliferation
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0051000biological_processpositive regulation of nitric-oxide synthase activity
C0010863biological_processpositive regulation of phospholipase C activity
C0051091biological_processpositive regulation of sequence-specific DNA binding transcription factor activity
C0045944biological_processpositive regulation of transcription from RNA polymerase II promoter
C0045893biological_processpositive regulation of transcription, DNA-templated
C0060527biological_processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
C0060523biological_processprostate epithelial cord elongation
C0071168biological_processprotein localization to chromatin
C0060687biological_processregulation of branching involved in prostate gland morphogenesis
C0043523biological_processregulation of neuron apoptotic process
C0006355biological_processregulation of transcription, DNA-templated
C0032355biological_processresponse to estradiol
C0043627biological_processresponse to estrogen
C0060009biological_processSertoli cell development
C0060011biological_processSertoli cell proliferation
C0007165biological_processsignal transduction
C0006366biological_processtranscription from RNA polymerase II promoter
C0006367biological_processtranscription initiation from RNA polymerase II promoter
C0006351biological_processtranscription, DNA-templated
C0060065biological_processuterus development
C0060068biological_processvagina development
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0016021cellular_componentintegral component of membrane
D0016020cellular_componentmembrane
D0005739cellular_componentmitochondrion
D0000790cellular_componentnuclear chromatin
D0005654cellular_componentnucleoplasm
D0005634cellular_componentnucleus
D0043204cellular_componentperikaryon
D0048471cellular_componentperinuclear region of cytoplasm
D0005886cellular_componentplasma membrane
D0043234cellular_componentprotein complex
D0030315cellular_componentT-tubule
D0043195cellular_componentterminal bouton
D0035327cellular_componenttranscriptionally active chromatin
D0051117molecular_functionATPase binding
D0008013molecular_functionbeta-catenin binding
D0003682molecular_functionchromatin binding
D0001046molecular_functioncore promoter sequence-specific DNA binding
D0019899molecular_functionenzyme binding
D0030284molecular_functionestrogen receptor activity
D0034056molecular_functionestrogen response element binding
D0042562molecular_functionhormone binding
D0042802molecular_functionidentical protein binding
D0030235molecular_functionnitric-oxide synthase regulator activity
D0000978molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding
D0038052molecular_functionRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
D0005496molecular_functionsteroid binding
D0003707molecular_functionsteroid hormone receptor activity
D0003700molecular_functiontranscription factor activity, sequence-specific DNA binding
D0008134molecular_functiontranscription factor binding
D0001077molecular_functiontranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
D0008270molecular_functionzinc ion binding
D0008209biological_processandrogen metabolic process
D0001547biological_processantral ovarian follicle growth
D1990375biological_processbaculum development
D0071392biological_processcellular response to estradiol stimulus
D0006338biological_processchromatin remodeling
D0046697biological_processdecidualization
D0060750biological_processepithelial cell proliferation involved in mammary gland duct elongation
D0030520biological_processintracellular estrogen receptor signaling pathway
D0030518biological_processintracellular steroid hormone receptor signaling pathway
D0060749biological_processmammary gland alveolus development
D0060745biological_processmammary gland branching involved in pregnancy
D0010629biological_processnegative regulation of gene expression
D0046325biological_processnegative regulation of glucose import
D0043124biological_processnegative regulation of I-kappaB kinase/NF-kappaB signaling
D1901215biological_processnegative regulation of neuron death
D1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
D0043433biological_processnegative regulation of sequence-specific DNA binding transcription factor activity
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0000122biological_processnegative regulation of transcription from RNA polymerase II promoter
D0090209biological_processnegative regulation of triglyceride metabolic process
D0002076biological_processosteoblast development
D0007200biological_processphospholipase C-activating G-protein coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0050679biological_processpositive regulation of epithelial cell proliferation
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0048146biological_processpositive regulation of fibroblast proliferation
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0051000biological_processpositive regulation of nitric-oxide synthase activity
D0010863biological_processpositive regulation of phospholipase C activity
D0051091biological_processpositive regulation of sequence-specific DNA binding transcription factor activity
D0045944biological_processpositive regulation of transcription from RNA polymerase II promoter
D0045893biological_processpositive regulation of transcription, DNA-templated
D0060527biological_processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
D0060523biological_processprostate epithelial cord elongation
D0071168biological_processprotein localization to chromatin
D0060687biological_processregulation of branching involved in prostate gland morphogenesis
D0043523biological_processregulation of neuron apoptotic process
D0006355biological_processregulation of transcription, DNA-templated
D0032355biological_processresponse to estradiol
D0043627biological_processresponse to estrogen
D0060009biological_processSertoli cell development
D0060011biological_processSertoli cell proliferation
D0007165biological_processsignal transduction
D0006366biological_processtranscription from RNA polymerase II promoter
D0006367biological_processtranscription initiation from RNA polymerase II promoter
D0006351biological_processtranscription, DNA-templated
D0060065biological_processuterus development
D0060068biological_processvagina development
E0005737cellular_componentcytoplasm
E0005794cellular_componentGolgi apparatus
E0016021cellular_componentintegral component of membrane
E0016020cellular_componentmembrane
E0005739cellular_componentmitochondrion
E0000790cellular_componentnuclear chromatin
E0005654cellular_componentnucleoplasm
E0005634cellular_componentnucleus
E0043204cellular_componentperikaryon
E0048471cellular_componentperinuclear region of cytoplasm
E0005886cellular_componentplasma membrane
E0043234cellular_componentprotein complex
E0030315cellular_componentT-tubule
E0043195cellular_componentterminal bouton
E0035327cellular_componenttranscriptionally active chromatin
E0051117molecular_functionATPase binding
E0008013molecular_functionbeta-catenin binding
E0003682molecular_functionchromatin binding
E0001046molecular_functioncore promoter sequence-specific DNA binding
E0019899molecular_functionenzyme binding
E0030284molecular_functionestrogen receptor activity
E0034056molecular_functionestrogen response element binding
E0042562molecular_functionhormone binding
E0042802molecular_functionidentical protein binding
E0030235molecular_functionnitric-oxide synthase regulator activity
E0000978molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding
E0038052molecular_functionRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
E0005496molecular_functionsteroid binding
E0003707molecular_functionsteroid hormone receptor activity
E0003700molecular_functiontranscription factor activity, sequence-specific DNA binding
E0008134molecular_functiontranscription factor binding
E0001077molecular_functiontranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
E0008270molecular_functionzinc ion binding
E0008209biological_processandrogen metabolic process
E0001547biological_processantral ovarian follicle growth
E1990375biological_processbaculum development
E0071392biological_processcellular response to estradiol stimulus
E0006338biological_processchromatin remodeling
E0046697biological_processdecidualization
E0060750biological_processepithelial cell proliferation involved in mammary gland duct elongation
E0030520biological_processintracellular estrogen receptor signaling pathway
E0030518biological_processintracellular steroid hormone receptor signaling pathway
E0060749biological_processmammary gland alveolus development
E0060745biological_processmammary gland branching involved in pregnancy
E0010629biological_processnegative regulation of gene expression
E0046325biological_processnegative regulation of glucose import
E0043124biological_processnegative regulation of I-kappaB kinase/NF-kappaB signaling
E1901215biological_processnegative regulation of neuron death
E1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
E0043433biological_processnegative regulation of sequence-specific DNA binding transcription factor activity
E0048662biological_processnegative regulation of smooth muscle cell proliferation
E0000122biological_processnegative regulation of transcription from RNA polymerase II promoter
E0090209biological_processnegative regulation of triglyceride metabolic process
E0002076biological_processosteoblast development
E0007200biological_processphospholipase C-activating G-protein coupled receptor signaling pathway
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
E0050679biological_processpositive regulation of epithelial cell proliferation
E0070374biological_processpositive regulation of ERK1 and ERK2 cascade
E0048146biological_processpositive regulation of fibroblast proliferation
E0045429biological_processpositive regulation of nitric oxide biosynthetic process
E0051000biological_processpositive regulation of nitric-oxide synthase activity
E0010863biological_processpositive regulation of phospholipase C activity
E0051091biological_processpositive regulation of sequence-specific DNA binding transcription factor activity
E0045944biological_processpositive regulation of transcription from RNA polymerase II promoter
E0045893biological_processpositive regulation of transcription, DNA-templated
E0060527biological_processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
E0060523biological_processprostate epithelial cord elongation
E0071168biological_processprotein localization to chromatin
E0060687biological_processregulation of branching involved in prostate gland morphogenesis
E0043523biological_processregulation of neuron apoptotic process
E0006355biological_processregulation of transcription, DNA-templated
E0032355biological_processresponse to estradiol
E0043627biological_processresponse to estrogen
E0060009biological_processSertoli cell development
E0060011biological_processSertoli cell proliferation
E0007165biological_processsignal transduction
E0006366biological_processtranscription from RNA polymerase II promoter
E0006367biological_processtranscription initiation from RNA polymerase II promoter
E0006351biological_processtranscription, DNA-templated
E0060065biological_processuterus development
E0060068biological_processvagina development
F0005737cellular_componentcytoplasm
F0005794cellular_componentGolgi apparatus
F0016021cellular_componentintegral component of membrane
F0016020cellular_componentmembrane
F0005739cellular_componentmitochondrion
F0000790cellular_componentnuclear chromatin
F0005654cellular_componentnucleoplasm
F0005634cellular_componentnucleus
F0043204cellular_componentperikaryon
F0048471cellular_componentperinuclear region of cytoplasm
F0005886cellular_componentplasma membrane
F0043234cellular_componentprotein complex
F0030315cellular_componentT-tubule
F0043195cellular_componentterminal bouton
F0035327cellular_componenttranscriptionally active chromatin
F0051117molecular_functionATPase binding
F0008013molecular_functionbeta-catenin binding
F0003682molecular_functionchromatin binding
F0001046molecular_functioncore promoter sequence-specific DNA binding
F0019899molecular_functionenzyme binding
F0030284molecular_functionestrogen receptor activity
F0034056molecular_functionestrogen response element binding
F0042562molecular_functionhormone binding
F0042802molecular_functionidentical protein binding
F0030235molecular_functionnitric-oxide synthase regulator activity
F0000978molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding
F0038052molecular_functionRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
F0005496molecular_functionsteroid binding
F0003707molecular_functionsteroid hormone receptor activity
F0003700molecular_functiontranscription factor activity, sequence-specific DNA binding
F0008134molecular_functiontranscription factor binding
F0001077molecular_functiontranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
F0008270molecular_functionzinc ion binding
F0008209biological_processandrogen metabolic process
F0001547biological_processantral ovarian follicle growth
F1990375biological_processbaculum development
F0071392biological_processcellular response to estradiol stimulus
F0006338biological_processchromatin remodeling
F0046697biological_processdecidualization
F0060750biological_processepithelial cell proliferation involved in mammary gland duct elongation
F0030520biological_processintracellular estrogen receptor signaling pathway
F0030518biological_processintracellular steroid hormone receptor signaling pathway
F0060749biological_processmammary gland alveolus development
F0060745biological_processmammary gland branching involved in pregnancy
F0010629biological_processnegative regulation of gene expression
F0046325biological_processnegative regulation of glucose import
F0043124biological_processnegative regulation of I-kappaB kinase/NF-kappaB signaling
F1901215biological_processnegative regulation of neuron death
F1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
F0043433biological_processnegative regulation of sequence-specific DNA binding transcription factor activity
F0048662biological_processnegative regulation of smooth muscle cell proliferation
F0000122biological_processnegative regulation of transcription from RNA polymerase II promoter
F0090209biological_processnegative regulation of triglyceride metabolic process
F0002076biological_processosteoblast development
F0007200biological_processphospholipase C-activating G-protein coupled receptor signaling pathway
F0007204biological_processpositive regulation of cytosolic calcium ion concentration
F0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
F0050679biological_processpositive regulation of epithelial cell proliferation
F0070374biological_processpositive regulation of ERK1 and ERK2 cascade
F0048146biological_processpositive regulation of fibroblast proliferation
F0045429biological_processpositive regulation of nitric oxide biosynthetic process
F0051000biological_processpositive regulation of nitric-oxide synthase activity
F0010863biological_processpositive regulation of phospholipase C activity
F0051091biological_processpositive regulation of sequence-specific DNA binding transcription factor activity
F0045944biological_processpositive regulation of transcription from RNA polymerase II promoter
F0045893biological_processpositive regulation of transcription, DNA-templated
F0060527biological_processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
F0060523biological_processprostate epithelial cord elongation
F0071168biological_processprotein localization to chromatin
F0060687biological_processregulation of branching involved in prostate gland morphogenesis
F0043523biological_processregulation of neuron apoptotic process
F0006355biological_processregulation of transcription, DNA-templated
F0032355biological_processresponse to estradiol
F0043627biological_processresponse to estrogen
F0060009biological_processSertoli cell development
F0060011biological_processSertoli cell proliferation
F0007165biological_processsignal transduction
F0006366biological_processtranscription from RNA polymerase II promoter
F0006367biological_processtranscription initiation from RNA polymerase II promoter
F0006351biological_processtranscription, DNA-templated
F0060065biological_processuterus development
F0060068biological_processvagina development
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC18BINDING SITE FOR RESIDUE EST A 600
ChainResidue
AHOH3
ALEU346
AGLU353
ALEU387
ALEU391
AARG394
AHIS524
ALEU525

AC26BINDING SITE FOR RESIDUE EST B 600
ChainResidue
BHOH22
BLEU346
BGLU353
BARG394
BHIS524
BLEU525

AC37BINDING SITE FOR RESIDUE EST C 600
ChainResidue
CHOH41
CLEU346
CGLU353
CLEU391
CARG394
CHIS524
CLEU525

AC46BINDING SITE FOR RESIDUE EST D 600
ChainResidue
DHOH60
DLEU346
DGLU353
DARG394
DHIS524
DLEU525

AC56BINDING SITE FOR RESIDUE EST E 600
ChainResidue
EHOH79
ELEU346
EGLU353
EARG394
EHIS524
ELEU525

AC67BINDING SITE FOR RESIDUE EST F 600
ChainResidue
FHOH98
FGLU353
FLEU387
FLEU391
FARG394
FHIS524
FLEU525

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
EST_1ere_A_60019ESTRADIOL binding site
ChainResidueligand
AMET343EST: ESTRADIOL
ALEU346-THR347EST: ESTRADIOL
ALEU349-ALA350EST: ESTRADIOL
AGLU353EST: ESTRADIOL
ALEU384EST: ESTRADIOL
ALEU387-MET388EST: ESTRADIOL
ALEU391EST: ESTRADIOL
AARG394EST: ESTRADIOL
APHE404EST: ESTRADIOL
AMET421EST: ESTRADIOL
AILE424EST: ESTRADIOL
ALEU428EST: ESTRADIOL
AGLY521EST: ESTRADIOL
AHIS524-LEU525EST: ESTRADIOL
AMET528EST: ESTRADIOL

EST_1ere_B_60019ESTRADIOL binding site
ChainResidueligand
BMET343EST: ESTRADIOL
BLEU346-THR347EST: ESTRADIOL
BLEU349-ALA350EST: ESTRADIOL
BGLU353EST: ESTRADIOL
BLEU384EST: ESTRADIOL
BLEU387-MET388EST: ESTRADIOL
BLEU391EST: ESTRADIOL
BARG394EST: ESTRADIOL
BPHE404EST: ESTRADIOL
BMET421EST: ESTRADIOL
BILE424EST: ESTRADIOL
BLEU428EST: ESTRADIOL
BGLY521EST: ESTRADIOL
BHIS524-LEU525EST: ESTRADIOL
BMET528EST: ESTRADIOL

EST_1ere_C_60019ESTRADIOL binding site
ChainResidueligand
CMET343EST: ESTRADIOL
CLEU346-THR347EST: ESTRADIOL
CLEU349-ALA350EST: ESTRADIOL
CGLU353EST: ESTRADIOL
CLEU384EST: ESTRADIOL
CLEU387-MET388EST: ESTRADIOL
CLEU391EST: ESTRADIOL
CARG394EST: ESTRADIOL
CPHE404EST: ESTRADIOL
CMET421EST: ESTRADIOL
CILE424EST: ESTRADIOL
CLEU428EST: ESTRADIOL
CGLY521EST: ESTRADIOL
CHIS524-LEU525EST: ESTRADIOL
CMET528EST: ESTRADIOL

EST_1ere_D_60019ESTRADIOL binding site
ChainResidueligand
DMET343EST: ESTRADIOL
DLEU346-THR347EST: ESTRADIOL
DLEU349-ALA350EST: ESTRADIOL
DGLU353EST: ESTRADIOL
DLEU384EST: ESTRADIOL
DLEU387-MET388EST: ESTRADIOL
DLEU391EST: ESTRADIOL
DARG394EST: ESTRADIOL
DPHE404EST: ESTRADIOL
DMET421EST: ESTRADIOL
DILE424EST: ESTRADIOL
DLEU428EST: ESTRADIOL
DGLY521EST: ESTRADIOL
DHIS524-LEU525EST: ESTRADIOL
DMET528EST: ESTRADIOL

EST_1ere_E_60019ESTRADIOL binding site
ChainResidueligand
EMET343EST: ESTRADIOL
ELEU346-THR347EST: ESTRADIOL
ELEU349-ALA350EST: ESTRADIOL
EGLU353EST: ESTRADIOL
ELEU384EST: ESTRADIOL
ELEU387-MET388EST: ESTRADIOL
ELEU391EST: ESTRADIOL
EARG394EST: ESTRADIOL
EPHE404EST: ESTRADIOL
EMET421EST: ESTRADIOL
EILE424EST: ESTRADIOL
ELEU428EST: ESTRADIOL
EGLY521EST: ESTRADIOL
EHIS524-LEU525EST: ESTRADIOL
EMET528EST: ESTRADIOL

EST_1ere_F_60019ESTRADIOL binding site
ChainResidueligand
FMET343EST: ESTRADIOL
FLEU346-THR347EST: ESTRADIOL
FLEU349-ALA350EST: ESTRADIOL
FGLU353EST: ESTRADIOL
FLEU384EST: ESTRADIOL
FLEU387-MET388EST: ESTRADIOL
FLEU391EST: ESTRADIOL
FARG394EST: ESTRADIOL
FPHE404EST: ESTRADIOL
FMET421EST: ESTRADIOL
FILE424EST: ESTRADIOL
FLEU428EST: ESTRADIOL
FGLY521EST: ESTRADIOL
FHIS524-LEU525EST: ESTRADIOL
FMET528EST: ESTRADIOL

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Nuclear receptor.
ChainResidueDetails
ANA*

SWS_FT_FI21Nuclear receptor.
ChainResidueDetails
BNA*

SWS_FT_FI31Nuclear receptor.
ChainResidueDetails
CNA*

SWS_FT_FI41Nuclear receptor.
ChainResidueDetails
DNA*

SWS_FT_FI51Nuclear receptor.
ChainResidueDetails
ENA*

SWS_FT_FI61Nuclear receptor.
ChainResidueDetails
FNA*

?

Catalytic Information from CSA

site_idNumber of ResiduesDetails
?

Catalytic Information from CATRES

site_idNumber of ResiduesDetails

> Sequence Neighbor

> Downloads

Resources

File formatFile name (file size)
PDBallpdb1ere.ent.gz (238.63 KB)
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all (no-compress)pdb1ere.ent (982.05 KB)
header onlypdb1ere.ent.gz (8.33 KB)
Display
PDBx/mmCIF1ere.cif.gz (286.35 KB)
PDBMLall1ere.xml.gz (446.64 KB)
Display
no-atom1ere-noatom.xml.gz (49.21 KB)
Display
ext-atom1ere-extatom.xml.gz (271.38 KB)
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PDBMLplusall1ere-plus.xml.gz (454.96 KB)
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no-atom1ere-plus-noatom.xml.gz (57.53 KB)
Display
add only1ere-add.xml.gz (8.32 KB)
Display
RDF1ere.rdf.gz (95.22 KB)
Display
Structure factorsr1eresf.ent.gz (310.86 KB)
Biological unit (PDB format)1ere.pdb1.gz (80.38 KB) (A,B)
*author and software defined assembly, 2 molecule(s) (dimeric)
Display
1ere.pdb2.gz (80.38 KB) (C,D)
*author and software defined assembly, 2 molecule(s) (dimeric)
Display
1ere.pdb3.gz (79.69 KB) (E,F)
*author and software defined assembly, 2 molecule(s) (dimeric)
Display
Validation reportsPDF1ere​_validation.pdf.gz (328.78 KB)
Display
PDF-full1ere​_full​_validation.pdf.gz (385.85 KB)
Display
XML1ere​_validation.xml.gz (62.88 KB)
Display
PNG1ere​_multipercentile​_validation.png.gz (151.85 KB)
Display
SVG1ere​_multipercentile​_validation.svg.gz (929 B)
Display
Sequence (fasta)1ere​_seq.txt
Display

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