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3ERT

HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN

Replaces:  2ERT
Summary for 3ERT
Entry DOI10.2210/pdb3ert/pdb
DescriptorPROTEIN (ESTROGEN RECEPTOR ALPHA), 4-HYDROXYTAMOXIFEN (3 entities in total)
Functional Keywordsnuclear receptor, transcription factor, estrogen, antagonist
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Nucleus. Isoform 3: Nucleus: P03372
Total number of polymer chains1
Total formula weight30237.73
Authors
Shiau, A.K.,Barstad, D.,Loria, P.M.,Cheng, L.,Kushner, P.J.,Agard, D.A.,Greene, G.L. (deposition date: 1999-03-30, release date: 1999-04-08, Last modification date: 2023-09-06)
Primary citationShiau, A.K.,Barstad, D.,Loria, P.M.,Cheng, L.,Kushner, P.J.,Agard, D.A.,Greene, G.L.
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Cell(Cambridge,Mass.), 95:927-937, 1998
Cited by
PubMed: 9875847
DOI: 10.1016/S0092-8674(00)81717-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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