3HQR
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PHD2:MN:NOG:HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:Egl nine homolog 1 (E.C.1.14.11.-), Hypoxia-inducible factor 1 alpha
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2009-06-08
Release date:2009-07-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009
1LM8
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STRUCTURE OF A HIF-1A-PVHL-ELONGINB-ELONGINC COMPLEX
Descriptor:elongin B, elongin C, Von Hippel-Lindau disease tumor suppressor, Hypoxia-inducible factor 1 alpha
Authors:Min, J-H, Yang, H., Ivan, M., Gertler, F., Kaelin JR., W.G., Pavletich, N.P.
Deposit date:2002-04-30
Release date:2002-06-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Science, 296, 2002
1LQB
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CRYSTAL STRUCTURE OF A HYDROXYLATED HIF-1 ALPHA PEPTIDE BOUND TO THE PVHL/ELONGIN-C/ELONGIN-B COMPLEX
Descriptor:HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
Authors:Hon, W.C., Wilson, M.I., Harlos, K., Claridge, T.D., Schofield, C.J., Pugh, C.W., Maxwell, P.H., Ratcliffe, P.J., Stuart, D.I., Jones, E.Y.
Deposit date:2002-05-09
Release date:2002-07-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature, 417, 2002
3HQU
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PHD2:FE:UN9:PARTIAL HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:Egl nine homolog 1 (E.C.1.14.11.-), Hypoxia-inducible factor 1 alpha
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2009-06-08
Release date:2009-07-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009
4AJY
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VON HIPPEL-LINDAU PROTEIN-ELONGINB-ELONGINC COMPLEX, BOUND TO HIF1- ALPHA PEPTIDE
Descriptor:TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR
Authors:Van Molle, I., Thomann, A., Buckley, D.L., So, E.C., Lang, S., Crews, C.M., Ciulli, A.
Deposit date:2012-02-21
Release date:2012-11-14
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
Chem.Biol., 19, 2012
5L9B
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HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:Egl nine homolog 1 (E.C.1.14.11.29), LEU-ASP-LEU-GLU-MET-LEU-ALA-PRO-TYR-ILE-PRO-MET-ASP-ASP-ASP-PHE-GLN-LEU
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-10
Release date:2016-08-31
Modification date:2016-09-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
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