6GMR

pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol

Summary for 6GMR

Entry DOI	10.2210/pdb6gmr/pdb
Descriptor	Elongin-B, Elongin-C, Hypoxia inducible factor 1alpha, residues 559-577, ... (8 entities in total)
Functional Keywords	e3 ubiquitin ligase, von hippel lindau tumor supressor, protoc, fragment-based drug discovery, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	45584.66
Authors	Van Molle, I.,Lucas, X.,Ciulli, A. (deposition date: 2018-05-28, release date: 2018-08-08, Last modification date: 2018-09-05)
Primary citation	Lucas, X.,Van Molle, I.,Ciulli, A. Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61:7387-7393, 2018 Cited by PubMed: 30040896 DOI: 10.1021/acs.jmedchem.8b00842 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation